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Sertraline hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of sertraline and hydrogen chloride.A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder. 2020-03-31 · Sertraline is used to treat depression, panic attacks, obsessive-compulsive disorder, post traumatic stress disorder and social anxiety disorder. It is sometimes prescribed to treat premenstrual dysphoric disorder, sexual problems and headaches. Sertraline should be taken exactly as prescribed and should not be stopped unless advised by a doctor.
Drug information. Drug name: Sertraline 15 Jul 2016 Sertraline hydrochloride has low solubility and undergoes first-pass metabolism resulting in low bioavailability. The main objective of this Upon login, all prices will be displayed in the currency assigned to your account. Sertraline Hydrochloride (100 mg).
2021-01-06 · Sertraline HCl (32μmol/kg i.p.) inhibits serotonin uptake into striatal synaptosomes from rats by more than 50%. Sertraline HCl is 6 times more potent than chlorimipramine and 60 times more potent than amitriptyline in reversing the 5-HT depletion elicited by PCA. Acute and repeated dosing of sertraline decreased serotonin content of whole blood. Sertraline is widely distributed, and its volume of distribution is estimated to be more than 20L/kg.
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She has served as the director of the Veterinary Behavior Clinic at University of Pennsylvania Veterinary Hospital and assistant professor of behavioral medicine at Penn’s School of Veterinary Medicine. See risks & benefits. Learn more about ZOLOFT® (sertraline HCl), a prescription treatment for depression. Sertraline hydrochloride is a white solid crystal or powder. It is soluble in water and slightly soluble in isopropyl alcohol.
The starting dose, 50 mg/day, is the usually effective therapeutic dose, and the optimal dose when considering both efficacy and tolerability for most patients.
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